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GLP-1 agonism: Reduces appetite, slows gastric emptying, promotes satiety GIP agonism: Enhances insulin secretion, may reduce GLP-1-related nausea Glucagon agonism: Increases hepatic glucose output control, drives thermogenesis and energy expenditure Phase 2 clinical trial data published in 2023 showed subjects lost an average of 24.2% of body weight over 48 weeks making it arguably the most potent weight-loss compound currently known

These lifestyle improvements bring joy and fulfillment beyond what the scale shows

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The rationale is mechanistic extrapolation, not demonstrated synergy

Better blood sugar control helps your body efficiently use food and nutrients for energy instead of storing them as fat