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Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of Apoe / mice

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CYP4F2 is a vitamin K(1) (VK1) oxidase and carriers of the CYP4F2 V433M allele (rs2108622 ) have a reduced capacity to metabolize VK1, secondary to an rs2108622 -dependent decrease in steady-state hepatic concentrations of the enzyme

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