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Taken together, these findings suggest that l-carnitine is a potent drug that increases the phosphorylation of AMPK and ACC to reduce synovial inflammation in the LPS-stimulated FLS model

Maintenance / taper: after a defined cycle, the research pattern is to pause

The investigator was blinded to the group allocation during the experiment

He noted that a similar rebound effect might occur with alcohol consumption once the medication is stopped

This extended duration is why a once-weekly schedule works so effectivelythe medication builds up in your system to reach therapeutic levels, then gradually decreases before your next dose arrives