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Godfrey H, Leibovit-Reiben Z, Jedlowski P, Thiede R

Tirzepatide (Mounjaro, Zepbound) is an FDA-approved dual GIP/GLP-1 receptor agonist for type 2 diabetes and chronic weight management

Overall, current evidence suggests that combination therapy is biologically plausible and clinically promising, but definitive conclusions regarding incremental benefit in established HF await dedicated randomized outcome trials

Editorial Notes: This article was edited by a Neuroscience News editor

As a result, new indications for weight management have emerged: for example, liraglutide (Saxenda) and semaglutide (Wegovy) are FDA-approved for chronic weight control, often at higher doses