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These compounds were largely found unstable in the active site pocket because of their relatively smaller size, as can be seen in RMSD and RMSF graphs in Fig

We included peer-reviewed randomized controlled trials, meta-analyses, and high-quality narrative or systematic reviews written in English that evaluated the effects of GLP-1 receptor agonists (liraglutide, semaglutide, or related analogues), as well as dual GIP/GLP-1 receptor agonists (such as tirzepatide), exercise training, or their combination on weight loss, body composition, metabolic, or cardiovascular outcomes in adults with obesity or type 2 diabetes

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Idiopathic intracranial hypertension, polycystic-ovary syndrome, and thrombophilia

Start low and titrate slowly to reduce gastrointestinal effects