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GLP-1 therapy starts at a low dose and titrates gradually to minimize gastrointestinal side effects the most common being nausea, particularly during dose increases

10.1007/s13346-018-00613-y [DOI] [PubMed] [Google Scholar] Bolaman Z., Kadikoylu G., Yukselen V., Yavasoglu I., Barutca S., Senturk T

19,20 Central Nervous Pathways Associated with GLP-1RAs Treatment Outcomes Application of GLP-1RAs is associated with a reduction in major adverse cardiovascular events, microvascular diseases, injury of peripheral nervous system, and improved glucose control (Figure 1)

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You can read the abstract of this article at Alcohol and Dopamine Dopamine signaling is crucial for transmitting motivational signals in the brain