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With a diverse population come diverse challenges and so these European powerhouses are continuing to grow and adapt in an increasingly complex and unpredictable geopolitical and economic landscape." While the Fortune list for Europe includes many young and emerging companies, the companies listed are largely mature, with an average age of 108 years and a median age of 100

The primary measure of treatment effect was tobacco smoking cessation at the longest follow-up available (a minimum of 6 months) using biochemically validated cessation where available