lettuce leaf cigarettes I have an unopened pack of from the 1970s that had in them instead of tobacco to help quit smoking. : r/mildlyinteresting Quit Smoking With Herbal Cigarettes

In a brief literature search, I could not find a clear answer for how much harm reduction comes from reducing the number of daily cigarettes

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Emily Kinkead said

These chemicals create the flavors and other characteristics of vape liquid

However the biggest killer is 'nicotine