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Obrador, E., Salvador-Palmer, R., Lopez-Blanch, R., Dellinger, R

Stringent regulations can delay product launches and increase costs, especially for companies seeking to expand internationally

Risk of sight-threatening diabetic retinopathy with glucagon-like peptide-1 receptor agonist use in routine clinical practice: Comparative effectiveness of semaglutide, dulaglutide, liraglutide, and exenatide

The decision to terminate the clinical development of Lotiglipron was based on the pharmacokinetic data from the clinical Phase 1 drug-drug interaction studies (NCT05671653 and NCT05788328), as well as the laboratory measurements of elevated transaminases in these Phase 1 studies and the ongoing Phase 2 study (NCT05579977)

[Abstract]2025 Dec:257:174114