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Tirzepatide is a novel glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus and chronic weight management

However, most available evidence is derived from in vitro studies, and the reported mechanisms largely reflect downstream signaling and biomarker changes under experimental conditions

Consequently, the effects of manipulating tryptophan levels on sleep and mood have been investigated in a number of studies

Enhanced glutamine uptake influences composition of immune cell infiltrates in breast cancer

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