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As the body adapts over time, ghrelin secretion may gradually normalize

This facilitates bacterial translocation and the entry of gutderived toxins (e.g., LPS) into the portal circulation, activating hepatic immune cells and exacerbating liver inflammation

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The mechanism of action does not directly involve the coagulation cascade or platelet function, which has led to questions about whether these medications might influence thrombotic risk

Seran ideales los estudios doble ciego, controlados, con distribucin al azar, con nmero significativo de pacientes que comparen la combinacin simultnea, secuencial o ambas para evaluar si los efectos son similares y teniendo en cuenta iSGLT (especficos y duales) y AGLP1 de accin larga, corta o ambas