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Klausen et al., 2022)

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Amgen CEO Robert Bradway stated that the company lowered the price "to reflect evolocumab's proven cardiovascular benefit and to improve patient access." The 2018 AHA/ACC Multisociety Guideline on the Management of Blood Cholesterol positioned PCSK9 inhibitors as reasonable add-on therapy for very high-risk ASCVD patients whose LDL-C remains at or above 70 mg/dL on maximally tolerated statin plus ezetimibe