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Hepatology 42: 962973

Ceramides activate a protein phosphatase that dephosphorylates AKT/protein kinase B, resulting in inhibition of GLUT4 translocation and glycogen synthesis [33, 34]

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When symptoms do occur, they may include 7,46,47 : Debilitating fatigue Itching and numbness Headaches Muscle cramps Weight loss Sleep disturbances Lack of appetite Nausea and vomiting Shortness of breath Seizures Edema (swelling) of the extremities CKD is often discovered in people who do not have significant symptoms when they either attend their yearly physical and undergo lab testing or have blood work done for other reasons