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2009;91(4 Suppl):15369

10.1186/s13048-018-0392-1 83 McDougallA.HastieR.GoldsteinM.TuttleA.TongS.AmmerdorfferA.et al (2022)

At the same time, changes in estrogen and other signaling chemicals affect sexual desire and mood

Key Effects: Kidney-Focused Regulation Acts on renal proximal tubules independently of insulin

Where appetite is the dominant driver of weight: the GLP-1/GIP dual mechanism of tirzepatide already addresses appetite and satiety powerfully, and adding a third receptor may offer diminishing marginal benefit for this specific lever