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What Happens with Chronic Stress: Cortisol dysregulation can lead to immune imbalance and rebound inflammation Skin barrier function decreases , leading to dryness, irritation, and flares Hormone levels like estrogen, progesterone, and thyroid can become disrupted Cortisol resistance may develop, where tissues no longer respond effectivelyresulting in inflammation thats harder to control In women, stress also affects menstrual cycles, which can worsen hormone-related eczema