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Patients feel this as frustration and urgency, because access becomes a contest between urgent need and limited supply

In another study, semaglutide exhibited greater potency in activating GLP-1R compared to GLP-1, with an EC50 of 6.2 pM for semaglutide vs 16.2 pM for GLP-1 (95) (The variability in EC50 values among different studies for GLP-1 was not uncommon attributable to varying assay conditions)

First, the researchers observed through direct measurement that skin cells were taking up and accumulating ergothioneine [9] -- the OCTN1 transporter functions as expected

This suggests semaglutide preferentially targets fat stores rather than causing indiscriminate tissue loss

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