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We conducted subgroup analyses based on prespecified risk factors, including age, sex, BMI, degree of liver fibrosis (FIB-4 score 1.3 among patients without cirrhosis), and diabetes severity (diabetes complications)

Examples of the latter include the Hrd1 and Der1 TMDs, which create a hydrophilic hole at the cytoplasmic side of the ER membrane, decreasing lipid bilayer thickness and facilitating substrate translocation

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