Abbreviations AMLN : Amylin liver nonalcoholic steatohepatitis ER : Endoplasmic reticulum FFA : free fatty acids FFD : Fast-food diet GAN : Gubra amylin GLP-1RAs : Glucagon-like peptide-1 receptor agonists HFCC : High-fat high-cholesterol high-cholic acid HFCC-CDX : High-fat high-cholesterol high-cholic acid diet with hydroxypropyl--cyclodextrin in drinking water HFD : High-fat diet HTFD : High-trans-fat high-fructose high-cholesterol diet MCD : Methionine-choline deficient NAFLD : Nonalcoholic fatty liver disease NLRP3 : Nod-like receptor protein amilypyrin domain containing 3 ROS : Reactive oxygen species SD : Sprague-Dawley TNF- : Tumor necrosis factor- References Henry L, Paik J, Younossi ZM (2022) Review article: the epidemiologic burden of non-alcoholic fatty liver disease across the world
95% CI, 1.61-1.71) compared to those with MASLD
Example Impacts: Kidney/Cardiovascular/Diabetes Drugs and Device Makers: A reduction in disease burden is likely to have a negative impact on demand for drugs, devices, software and services related to these conditions
But for employers and insurance brokers, the conversation has shifted from Should we cover GLP-1s? to How can we cover them responsibly? According to the U.S
45, 54 Our findings that normal pancreatic acinar cells have a low level of expression of GLP-1R is similar to those from some reports 60, 61 but differ from others, which report no GLP-1R in normal pancreatic acinar cells by assessing GLP-1R mRNA levels
