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Traditional inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-) have been widely used for risk assessment
Both the STEP and SUSTAIN trials found that placebo groups also reported joint pain, suggesting other factors may contribute
A comparison of LY2112688 and MC-agonist setmelanotide suggests that the cardiac liabilities of LY2112688 are a molecule-specific limitation, rather than a general feature of MC4R agonism
Versus Steroids: Corticosteroids suppress inflammation but weaken tissue over time
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