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Evidence from the midspan prospective cohort studies using mention of diabetes mellitus on hospital discharge or death records [1]

It is a prescription drug in most jurisdictions, approved by the FDA for acne and, in specific formulations, for the treatment of photoaging (fine wrinkling, mottled hyperpigmentation, and roughness)

Neurosci Biobehav Rev 173: 106159

If you add just a little bit of weight training to the more aerobic things it doesn't take all that much to derive the core benefits

Hepatic gluconeogenesis and insulin sensitivity were improved in ob/ob mice treated with recombinant adenovirus expressing GLP-1 (rAd-GLP-1) [22]