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Additionally, patients with constipation-predominant IBS (IBS-C) exhibit significantly lower serum GLP-1 levels, which negatively correlate with abdominal pain scores

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2.2.1 ACSL 4/LPCAT 3 A synthetase long-chain family (ACSL) is a major enzyme involved in lipid metabolism in vivo , notably facilitating the production of fatty acids with carbon chains ranging from 12 to 20 (53)

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Structural modifications such as the type and position of substituents and the degree of hydroxylation can directly influence the physicochemical properties, biological activities, and pharmacological profiles of different flavonoid subclasses (Zouaoui et al., 2021

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