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"Contribution of the active metabolite M1 to the pharmacological activity of tesofensine in vivo: a pharmacokinetic-pharmacodynamic modelling approach"
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doi: 10.1136/egastro-2023-100057 30 MolnrGGyarmathyVAZdoriNHegyiPKanizsaiP
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Additional pharmacological characterization by our group corroborates its hMC3R potency (EC 50 = 4.2 nM, E max = 91%) and demonstrates enhanced hMC4R potency (EC 50 = 0.048 nM, E max = 100%) (25)
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