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The MTHFD2 enzyme is resistant to inhibition by NADH and so this reaction can contribute to significant mitochondrial NADH production under increased serine catabolism as well as during periods where the major NADH producing catabolic pathways are inhibited by increasing NADH levels

To improve effectiveness, take them with vitamin C to enhance absorption

J.AngenendtP.et al

found that histidine catabolism affects the sensitivity of cells to methotrexate, and dietary supplementation of histidine maintains a suitable chemotherapy effect with a low dose of medication

One study showed that KD and MD may benefit patients with psoriasis (205)