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CRF-expressing neurons are abundant in the hypothalamic PVN where they control the pituitary-adrenal axis regulating the release of ACTH and glucocorticoids

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Moreover, the targets of dietary antioxidants could also be used as pharmacological targets to develop new drug-based therapies

Furthermore, pro-inflammatory cytokines which are generated from immune cells, such as TNF- and IL-1, are raised during SIRS to encourage the recruitment of immune cells into the brain parenchyma

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