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Copper peptides utilize the skin's biochemical systems that remove the old, hard cells and damaged proteins and replace them with new skin and new proteins
I've used up ampoules that are long out of date and have been subjected to fluctuating heat (terrible for wine!) due to being in my car, etc, and haven't noticed any difference
Symptoms of B12 deficiency include: Low energy and fatigue Digestive problems Depression and moodiness Insomnia Brain fog and memory loss Anemia Reduced immune system function Tingling or numbness in the extremities Swollen tongue Loss of vision or hearing Jaundice Kidney disease Pale skin Poor circulation in the extremities If you are over age 50 and are experiencing one or more of the above symptoms, boosting your intake of B12 cannot hurt, and it may provide a safe and inexpensive solution while preventing a wrong diagnosis
doi: 10.1007/BF02985220