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While other MC agonists are associated with cardiac side effects, treatment with MC4-NN20453 induced no clinically relevant changes in systolic or diastolic blood pressure in the SAD or MAD cohorts

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These criteria become especially important as GLP-1 medications receive rave news coverage that makes average people want to try them, even if they don't need them

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However, there was no evidence that using those conventional antidiabetic drugs resulted in significant cardiovascular benefits