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Available from: Sedatives and/or anesthetics may be used If necessary, a relaxation medication may be given through an intravenous (IV) line in the patients arm, but the patient is usually conscious during this procedure

The transdermal patches or gel are easy to use, although requiring a daily administration, are generally well accepted by the patients and allow mimicking the physiological circadian rhythm of testosterone

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De Simone R, Ajmone-Cat MA, Carnevale D, Minghetti L (2005) Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures

Ramadan et al