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Shaw PJ (2005) Molecular and cellular pathways of neurodegeneration in motor neurone disease

Although I could only find rat studies on PubMed, the peptide has generated excellent results in a Phase 2b clinical trial run by Metabolic Pharmaceuticals: The drug codenamed AOD9604 was taken orally once daily by 300 obese patients at five trial sites over a 12-week period

This can help to relieve pain and improve circulation

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This suggests that the cells rely on GPX4 to resist oxidative stress, and this could potentially increase their sensitivity to RSL3, a ferroptosis inducer that targets GPX4