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A recent study published in Diabetes Obesity and Metabolism found that individuals using these medications lost significant amounts of fat but also experienced some degree of muscle loss, with lean body mass reductions making up approximately 25%40% of total weight Trusted Source Changes in lean body mass with glucagon-like peptide-1-based therapies and mitigation strategies Neeland IJ, Linge J, Birkenfeld AL Go to Source loss

Nutritional status: Long-term semaglutide use requires attention to nutritional adequacy

If you miss multiple doses, discuss the best course of action with your doctor

The effects of these drugs on body weight regulation may be manifest through targets beyond appetite

This delayed gastric emptying is central to semaglutide's appetite-suppressing effects but can also contribute to reduced food intake