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Neuronal Slc25a39 knockout abolished FGF21-mediated protection against brain edema, lesion volume, and neurological deficits following TBI in mice Consistent with previous findings, the protective effects of FGF21 on lesion volume post-TBI were evident in Slc25a39 fl/fl mice but absent in Slc25a39 CKO mice

PMID 3710058