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Possible explanations for how HRT could adversely affect MASLD development include adverse effects from the progesterone component of HRT (which is infrequently considered in existing studies), nonphysiologically high hepatic estrogen exposure from oral estrogens, and the inability to replicate the natural oscillatory patterns of hepatic estrogen exposure in the premenopausal state (10)

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doi: 10.1016/j.niox.2012.03.004

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Methods: The pharmacokinetic profile and absolute bioavailability of the pure active markers were determined in male Wistar rats by administrating individually the doses of 1 100