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The science and translation of lactate shuttle theory

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Published binding studies have demonstrated 10-100 fold increased potency compared to native alpha-MSH at the MC1R

As previously discussed, the addition of the C-terminal hydrophobic residues isoleucine and alanine in A 142 favors oligomerization into the hexameric barrel shape and thus would increase both its antimicrobial and cytotoxic potential (Lendel et al., 2014

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