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Facilitates sympathetic outflow: Modulates autonomic functions by increasing sympathetic nervous system tone, which can affect cardiovascular responses, energy expenditure, and possibly explain sympathomimetic side effects 3,4

Cancer 48:257270 George JC, Edwards MK, Jakacki RI et al (1995) Melanotic neuroectodermal tumor of infancy

Repigmentation and new growth of hairs after anti-interleukin-17 therapy with secukinumab for psoriasis

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The specific deletion of SIRT6 activates the transcription of the transmembrane Notch receptors Notch1 and Notch4, reducing the anti-inflammatory and anti-apoptotic effects of SIRT6 in podocytes and exacerbating podocyte damage and proteinuria