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High levels of glutathione (GSH) are observed in the majority of tumors, contributing to cancer progression and treatment resistance in part by preventing glutathione peroxidase 4dependent (GPX4-dependent) ferroptosis

Unfortunately, it is difficult to assess potential sex differences in pharmacokinetics and tolerability of, for example, semaglutide, as a large fraction of the available data was either tested exclusively in male human, primate, or rat subjects (82) or not presented disaggregated by sex (83, 84)

& Peti-Peterdi, J