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Rasal RM, Janorkar AV, Hirt DE

Upon perfusion, OPTEC tubules displayed proper polarization and expressed a broad array of proximal-tubule-specific functional markers, exhibiting higher expression levels of basolateral drug transporters, namely organic cationic/carnitine transporter 2 (OCT2), organic anion transporter 1 (OAT1) and OAT3, compared to immortalized PTECs

Risks: Increased heart rate, potential worsening of heart failure with reduced ejection fraction, and rare complications like hypoglycemia or retinopathy

Shah VN, Akturk HK, Kruger D, Ahmann A, Bhargava A, Bakoyannis G, et al

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