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Excitotoxicity and Its Role in Neurodegenerative Diseases Excitotoxicity, the process by which excessive excitatory neurotransmitter release (primarily glutamate) damages neurons, is a critical mechanism in many neurological disorders: Alzheimer's Disease: In Alzheimer's, the accumulation of amyloid-beta plaques triggers an inflammatory response that sensitizes neurons to glutamate toxicity

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One aliquot is derivatised immediately for the determination of reduced glutathione