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Red flag symptoms requiring urgent medical assessment include: Severe abdominal pain or distension Rectal bleeding (especially in those aged 60 or over) Unexplained weight loss (beyond that expected from semaglutide therapy) Persistent vomiting Change in bowel habit lasting more than 6 weeks (especially in those over 60) Symptoms suggesting bowel obstruction (severe pain, vomiting, complete inability to pass stool or gas) These features may indicate complications or, rarely, underlying colorectal pathology requiring investigation in line with NICE suspected cancer pathways (NG12)

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