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The accumulated tissue changes in long-standing injuries mean more extensive remodeling is necessary for functional improvement

But "matters less" does not mean "does not matter at all." The initial 24 to 72 hours after injection represent a distinct pharmacokinetic phase where drug levels are rising rapidly

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Intermittent fasting (IF) is an eating protocol that involves alternating periods of fasting with periods of eating and has recently gained popularity as a strategy for reducing body weight (Erdem et al., 2022