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This is a commonly reported, short-lived response

Science: The seven deadly smells of a skunk

Tirzepatide works as a dual GIP/GLP-1 receptor agonist, meaning it targets two hormones instead of one

Compared to the native hormones, retatrutide shows 2.9-fold less potency at the glucagon receptor (GCCR), 2.5-fold less potency at the GLP-1 receptor, and 8.9-fold greater potency at human GIP receptor [1]