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Conversely, insulin resistance has been shown to cause imbalance in the redox status, pro versus anti-inflammatory cytokines and deranged lipid homeostasis with the resultant oxidative stress, inflammation and adiposity/obesity respectively in experimental animals [47-52]

Hyperglycemia stimulates the peroxidation of Low-Density Lipoprotein (LDL) through the superoxide-dependent signaling pathway to produce free radicals

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The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway