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PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner

Abbreviations 2-ME: 2-mercaptoethanol ACN: Acetonitrile BCPB: 1-benzyl-2-chloropyridinium bromide Captopril: [2 S]-1-[3-mercapto-2-methylpropionyl]-L-proline CMLT: 2-chloro-1-methyllepidinium tetrafluoroborate CMQT: 2-chloro-1-methylquinolinium tetrafluoroborate Cys: Cysteine DTT: Dithiothreitol FDA: United States Food and Drug Administration GSH: Glutathione Hcy: Homocysteine Hcy-thioalctone: Homocysteine-thiolactone HPLC-UV: High performance liquid chromatography with spectrophotometric detection LA: Lipoic acid MESNA: 2-mercaptoethanesulfonic acid MPG: N-(2-mercaptopropionyl)-glycine NAC: N-acetylcysteine N-Hcy-Lys: N-homocysteinyllysine RP-HPLC: Reverse-phase high performance liquid chromatography TCA: Trichloroacetic acid TCEP: tris(2-carboxyethyl)phosphine References Lu, S

This pathway neutralizes hydrogen peroxide radicals from metabolism

Left histograms from flow cytometry analyses of dihydrorhodamine 123 (DHR123) oxidation before (0 min) or after incubation of N