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When averaging together information from more than 100,000 people, the presence of an Lp(a) genetic variant caused an average decrease in lifespan of 1.5 years.[ref] This doesnt mean everyone with high Lp(a) dies early

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Loss of claudins 2 and 15 from mice causes defects in paracellular Na+ flow and nutrient transport in gut and leads to death from malnutrition

These robust in vitro and in vivo evidences collectively establish the indispensable physiological protective role of GPX4 in maintaining organismal redox homeostasis and defending against ferroptosis (Friedmann Angeli et al., 2014)