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Among Semaglutide comparisons, surgical rates showed no significant differences between Phentermine/Topiramate (HR 0.18, 95% CI 0.021.55, p = 0.08)

thejns.org/view/journals/ #OnlineFirst: Impact of GLP-1 receptor agonists on stroke, subarachnoid hemorrhage, and intracerebral hemorrhage: a propensity-matched multi-institutional cohort study

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This arises from animal studies that show the connection found between semaglutide and thyroid cancer, though its worth noting that there are currently no conclusive studies on humans yet

The higher 7.2 mg Wegovy dose produced an average weight loss of around 20.7% in its trial, so a larger weight loss is possible with Wegovy at that dose