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10.1128/IAI.00136-08

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This shows the differential responses of exercise training in different tissues presumably associated with their energy needs and metabolism

To further investigate how the three missense mutations (I20B Q, L23B R and V24B N, Figure 2) led to a significantly increased GLP-1R ECD binding affinity, a comprehensive structural biophysical analysis [34] was conducted for the 10000 structural models of semaglutide mutant 524 built by Modeller [29]