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Heme oxygenase 1 catalyzes the degradation of heme to free iron, biliverdin, and carbon monoxide (CO) thereby removing free heme which is pro-oxidant

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When the two amino acid changes Ala34Glu and Arg37Trp are introduced into human GR, the resulting mutant enzyme (GRTR) prefers trypanothione 700-fold over its original substrate, effectively converting a GR into a TR [Bradley, M., Bcheler, U

However, the degree of metabolic change at these lower doses remains uncertain

Inflammatory processes in alzheimers diseasepathomechanism, diagnosis and treatment: a review