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This highlights the significant promise in concurrently focusing on c-MET and PD-1/PD-L1 for treating tumors with c-MET/PD-L1 positivity

standardization and highpurity material are essential for translational relevance

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Seiwerth and colleagues (Inflammopharmacology, 1999) documented effects on angiogenic growth factor pathway signalling, and subsequent work has expanded characterisation to include VEGF receptor 2 upregulation, endothelial cell migration in capillary-formation assays, and improved healing in ischemia-reperfusion preparations

The main extrinsic factor is the sun, particularly with the contribution of UV rays and visible light [30, 32, 33]