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In circulation, the bioavailability of native IGF-1 is tightly regulated by a family of six IGF binding proteins (IGFBP-1 through IGFBP-6), which sequester ~99% of plasma IGF-1 and limit its receptor-accessible fraction

Many patients experience benefits that persist for several months after completing a full treatment cycle, especially when supported by healthy lifestyle habits

Cell Host Microbe 28(2):245257

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Possible side effects The most common side effects of Wegovy are digestive issues such as nausea, diarrhea, vomiting, constipation, indigestion and heartburn, gas and bloating, as well as headache, fatigue, dizziness, burping, runny nose or sore throat, and low blood pressure