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To view a copy of this licence, visit About this article Cite this article Zhou, X., Zhang, H., Wei, L

doi: 10.1038/ni.2730 63 MaceykaMSpiegelS

It is a coenzyme your cells already make from vitamin B3, and it is central to two things: shuttling electrons through energy metabolism, and serving as a required cofactor for sirtuins, PARPs, and CD38

doi:10.1093/jac/dkv147

Carrier-Mediated Transport (CMT) CMT of small molecules across the BBB occurs after the interaction between a substrate compound and the specific transport protein, which can be expressed in either the luminal or abluminal membrane or both sides of the brain capillary endothelial cells (Table I)