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Importantly, 3G10 binding induces only minor conformational changes in VP2 EF loop 135-143 and VP1 GH loop (Fig

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Xiaflex is also being developed for hammer toe, a common foot deformity where the toe bends abnormally at the middle joint, causing it to curl downward like a hammer, and completed a proof-of-concept study last year with a phase 3 trial due to start in the fourth quarter of this year