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In particular, accumulating evidence suggests that inflammation is a prominent etiology of OA, and that chondrocytes and synovial cells overproduce many of the soluble inflammatory mediators, such as cytokines, chemokines, growth factors, adipokines, prostaglandins, leukotrienes and regulators such as CPB [7, 8]

In the ACTION study, 3008 individuals with obesity and 606 healthcare providers were questioned on their obesity-related perceptions, attitudes, and behaviors

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Dose reductions of these agents may be necessary, and blood glucose monitoring should be intensified